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	Provedor de dados BJMBR (3) BJPS (1) Autor Banu,Sofia (1) Castro,M.S.A. (1) Criddle,D.N. (1) Duarte,I.D.G. (1) Francischi,J.N. (1) Nath,Kaberi (1) Pari,L. (1) Perez,A.C. (1) Rodrigues,A.R.A. (1) Sarkar,Purabi (1) Venkateswaran,S. (1) de Moura,R.S. (1) Mais... Palavra-chave Glibenclamide (4) Diabetes (2) Antioxidants/pharmacology (1) Baicalein/pharmacology (1) Collagen (1) Collagen glycation (1) Cross-linking (1) Diabetes Mellitus/ Experimental/prevention and control (1) Fentanyl (1) Gene Expression/drug effects (1) Glyburide/pharmacology (1) Human saphenous vein (1) K ATP (1) K+ channel (1) K+-channel (1) Levcromakalim (1) Nicotinamide/pharmacology (1) Peripheral antinociception (1) Phaseolus vulgaris (1) Rat aorta (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2019 (1) 2005 (1) 2003 (1) 2000 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Effect of an aqueous extract of Phaseolus vulgaris on the properties of tail tendon collagen of rats with streptozotocin-induced diabetes BJMBR Pari,L.; Venkateswaran,S.. Changes in the structural and functional properties of collagen caused by advanced glycation might be of importance for the etiology of late complications in diabetes. The present study was undertaken to investigate the influence of oral administration of aqueous pod extract (200 mg/kg body weight) of Phaseolus vulgaris, an indigenous plant used in Ayurvedic Medicine in India, on collagen content and characteristics in the tail tendon of streptozotocin-diabetic rats. In diabetic rats, collagen content (117.01 ± 6.84 mg/100 mg tissue) as well as its degree of cross-linking was increased, as shown by increased extent of glycation (21.70 ± 0.90 µg glucose/mg collagen), collagen-linked fluorescence (52.8 ± 3.0 AU/µmol hydroxyproline), shrinkage temperature... Tipo: Info:eu-repo/semantics/article Palavras-chave: Collagen; Diabetes; Phaseolus vulgaris; Cross-linking; Glibenclamide; Collagen glycation. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700006 Modulatory effect of baicalein on gene expression and activity of antioxidant enzymes in streptozotocin-nicotinamide induced diabetic rats BJPS Sarkar,Purabi; Nath,Kaberi; Banu,Sofia. Oxidative stress plays the central role in the pathogenesis and progression of diabetic complications. The present study aims to investigate the beneficial effect of oral administration of flavone baicalein in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats by measuring oxidative stress markers, antioxidant enzyme activities and expression analysis of antioxidant genes. Experimental diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (55 mg /kg b.wt), 15 min after the i.p. administration of NA. At the end of the experimental period, thiobarbituric acid reactive substances (TBARS), activities of antioxidant enzymes and expression levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Streptozotocin/pharmacology; Baicalein/pharmacology; Nicotinamide/pharmacology; Glibenclamide; Diabetes Mellitus/ Experimental/prevention and control; Gene Expression/drug effects; Antioxidants/pharmacology; Glyburide/pharmacology; Rats. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100508 Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats BJMBR Rodrigues,A.R.A.; Castro,M.S.A.; Francischi,J.N.; Perez,A.C.; Duarte,I.D.G.. We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid receptor agonist, to promote peripheral antinociception. Antinociception was measured by the paw pressure test in male Wistar rats weighing 180-250 g (N = 5 animals per group). Carrageenan (250 µg/paw) decreased the threshold of responsiveness to noxious pressure (delta = 188.1 ± 5.3 g). This mechanical hyperalgesia was reduced by fentanyl (0.5, 1.5 and 3 µg/paw) in a peripherally mediated and dose-dependent fashion (17.3, 45.3 and 62.6%, respectively). The selective blockers of ATP-sensitive K+ channels... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peripheral antinociception; Fentanyl; K+ channel; Μ-Opioid receptor agonist; Glibenclamide. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100014 Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta BJMBR Criddle,D.N.; de Moura,R.S.. The vasorelaxant effects of SR 47063 (4-(2-cyanimino-1,2-dihydropyrid-1-yl)-2,2-dimethyl-6-nitrochromene), a new K+-channel opener structurally related to levcromakalim, were examined in isolated human saphenous vein (HSV) and rat aorta (RA). HSV or RA rings were precontracted with either KCl or noradrenaline and cumulative relaxant concentration-response curves were obtained for SR 47063 (0.1 nM to 1 µM) in the presence or absence of 3 µM glibenclamide. SR 47063 potently relaxed HSV and RA precontracted with 20 mM (but not 60 mM) KCl or 10 µM noradrenaline in a concentration-dependent manner, showing slightly greater activity in the aorta. The potency of the effect of SR 47063 on HSV and RA was 12- and 58-fold greater, respectively, than that reported for... Tipo: Info:eu-repo/semantics/article Palavras-chave: SR 47063; K+-channel; Human saphenous vein; K ATP; Rat aorta; Levcromakalim; Glibenclamide. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800013 Registros recuperados: 4 Primeira ... 1 ... Última

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